Endocrine Abstracts

BackgroundThe usage of Immune checkpoint inhibitors such as pembrolizumab grows over time due to their positive effect on survival and quality of life in patients with advanced cancer. The frequency of immune-related adverse events (IRAEs) associated with this drugs grows over time accordingly. Several endocrine-IRAEs of pembrolizumab are described in the literature and the thyroid disfunction is the most common.Case description</p...

Introduction: Transsphenoidal surgery (TSS) is the treatment of choice for patients with acromegaly. However, even after radical surgery persistence of acromegaly may remain up to thirty percent by resent studies (Starnoni, 2016). Nadir growth hormone (GH) level less than 1.0 μg/l on an early postoperative oral glucose tolerance test (OGTT) have been suggested as early predictor of surgical remission (Kim 2012). However, the value of this approach remains to be defined.</...

Purpose: The postoperative levels of cortisol and ACTH are the most commonly used markers for the prediction of Cushing’s disease (CD) remission after transsphenoidal surgery (TSS). However, there is still no consensus on the collection time and threshold values of basal cortisol and ACTH levels after surgery to predict remission of CD.Aim: To study the significance of early postoperative serum cortisol and plasma ACTH testing in the prognosis of C...

Introduction: Growth hormone (GH) level is a direct marker of active residual adenoma tissue after acromegaly surgery. However, the value of early postoperative GH for prediction of surgical cure in acromegaly has not been established and therefore is not used in everyday clinical practice.Aim: The aim of our work was to study the 24-hour basal postoperative GH level and the nadir of GH level after the oral glucose tolerance test (OGTT) two weeks after s...